Found painless alternative to insulin injections

Novel pill could replace injections to deliver insulin says study

A new study shows that scientists have developed a drug capsule that could be used to deliver oral doses of insulin, potentially replacing injections for patients with Type-2 diabetes.

If you had a choice between injecting yourself with your medication or swallowing a capsule that contained your medication compressed into a needle which would you choose? The same capsule can also be adapted to deliver other protein drugs.

Several years ago, Traverso, Langer, and their colleagues developed a pill coated with many tiny needles that could be used to inject drugs into the lining of the stomach or the small intestine. The needle's shaft is built from a biodegradable material that doesn't enter the stomach wall. To power it, researchers bound a tiny spring to a hardened sugar disk. As the stomach wall does not possess pain receptors the researchers are hopeful that this could be a preferable method of administration compared to traditional injection. The researchers changed the new capsule so it has just one needle so that the drugs aren't injected into the stomach's insides and broken down by acids before they could have any effect. And for long time researchers have pursued a way to orally control insulin. The insulin needle then injects insulin through the stomach lining; the insulin is then absorbed into the blood stream.

In a news release, the MIT scientists said that the mechanism is inspired by the leopard tortoise, found in Africa. The leopard tortoise has an unusual shaped shell that looks like a high dome, if the tortoise rolls over, the shape of its shells ensures it can always easily self-right.

The group created computer models to design a variant of the shape for their capsule, which allows it to orient itself even in the stomach.

Injectable drugs, such as insulin and other large proteins, can be lifesavers.

Apple puts modem chip engineering in-house
Apple may have just made a move that will let it assert even more control over the parts it uses for its iPhones. Srouji has been associated with Apple since 2008 and has lead Apple's chip design department.

Fleetwood Mac's Lindsey Buckingham Undergoes Emergency Heart Surgery
Buckingham later sued Fleetwood Mac for breach of contact, and said in December the civil lawsuit had been settled out of court. As Rolling Stone notes, Buckingham and Fleetwood Mac parted ways acrimoniously a year ago , something that Kristen references.

Russian Official: Another Nuclear Pact with US in Trouble
We continue to present that intelligence and information to Russian Federation . "I will make every possible effort to prevent it", he said.

"Our motivation is to make it easier for patients to take medication, particularly medications that require an injection", said senior author Giovanni Traverso.

The research in pigs has successfully delivered up to 5 milligrams of insulin, comparable to the amount a type 2 diabetic patients would need to inject.

In addition, the oral device, also called SOMA, is capable of self-orienting, thanks to its shape and distribution of its density, so that the micro-needle is injected correctly into the stomach.

The researchers describe the capsule as "about the size of a pea" and made from biodegradable polymer and bits of stainless steel.

After the capsule releases its contents, it can pass harmlessly through the digestive system.

Other authors of this study include Alex Abramson, Ester Caffarel-Salvador, Minsoo Khang, David Dellal, David Silverstein, Yuan Gao, Morten Revsgaard Frederiksen, Andreas Vegge, František Hubálek, Jorrit J. Water, Anders V. Friderichsen, Johannes Fels, Rikke Kaae Kirk, Cody Cleveland, Joy Collins, Siddartha Tamang, Alison Hayward, Tomas Landh, Stephen T. Buckley, Niclas Roxhed, and Ulrik Rahbek. MIT teamed up with pharmaceutical company Norvo Nordisk for the research.

Related:

Comments

Latest news

Wedding descends into chaos after groom hits on teen waitress
Aimers was released on Wednesday, Feb. 6 after posting 10 percent of his $350,000 bail, The Philadelphia Inquirer reported . He told the young girl, whose name or age has not been revealed, they could do "whatever" she wanted, the affidavit states.

Warren: 'I Am a Candidate for President'
The expected launch will test whether the controversy is simply a Washington obsession or a substantive threat to her candidacy. We can't afford just to tinker around the edges, a tax credit here, a regulation there. "It's time to fight back", Warren said.

Capsule to carry US astronauts to be tested in March
The unpiloted capsule will execute an autonomous rendezvous with the space station, moving in for docking the day after launch. Boeing plans to follow the unpiloted test flight with a launch pad abort test in the June timeframe.

ESA Mars rover named after Rosalind Franklin, brilliant DNA pioneer
The rover is part of the mission's second phase, which is scheduled to launch in 2020 and land on the Red Planet in March 2021. The mission is a joint project between the European and Russian space agencies.

Five juveniles arrested and charged after 24-year-old is killed
They say they're saddened by his loss and are doing everything they can to support his friends and family at this time. Witnesses on Timberland Drive told police they saw three juveniles get out of the pickup truck.

Assassin's Creed III Remastered Comparison Trailer and Launch Date
Assassin's Creed Odyssey is an ambitious role-playing game that places choice at the center of the experience. And everyone else will be able to purchase it as a standalone game for $39.99 for the PC, PS4, and Xbox One.

Vivo upgrades its cool pop-up selfie camera with massive number of megapixels
The company has now teased the V15 Pro on Amazon India website confirming that the phone will be available on the website itself. The page has revealed that the V15 Pro will come with 32MP pop-up selfie camera and main rear camera has been of a 48MP sensor.

Watch Ellen DeGeneres Grill Kendall Jenner About Ben Simmons
There were rumors that Scott was going to propose to his girlfriend during his half-time show performance, but it didn't happen. Love her. "No, she's not", Jenner said with a laugh. "If if he did, she hasn't told the family yet", Kendall said.

Hooch kills 40 in 48 hrs in UP, Uttarakhand
The viscera examination on 11 more bodies is yet to be conducted to find out if these too were alcohol-related deaths. Authorites fear the toll will rise as deaths linked to illicit liquor have been reported in other regions.

Sprint sues AT&T, claiming 'deceptive' and illegal 5GE branding
Now there's no getting around the fact that 5G E is impressively fast, but to be clear, that's not what Sprint's lawsuit is about. They don't think they are misleading customers, will continue to push the 5G Evolution message, and will fight Sprint's lawsuit.

Gary Lineker fears for Harry Kane amid recurring ankle injuries
The north Londoners are set to enter a crunch period and if all goes to plan, Kane will return for a crucial run of fixtures.

Everything Apex Legends Doesn't Tell You: Tips For Becoming A Champion
Seeing as both titles are free-to-play Battle Royale games, this is not a surprising business decision for Epic Games to make. Players who perform a Google search for Apex Legends have a chance of receiving an ad for Epic's Fortnite Battle Royale.

How to invite friends to the Division 2 Beta
Friends who already preordered the game or have already been invited to the game will not be able to receive additional invites. If you pre-ordered the game at retail, then you should have been given a code that can be redeemed on the pre-order website .

More Winter Weather: Freezing Rain and Ice Pellets
It warns freezing rain Thursday and high winds early Friday could cause more problems, like downed wires or other safety hazards. So this will also contribute to the slippery roads, and reduce visibility for the morning commute tomorrow.

London Zoo tiger killed after being introduced to male for first time
Keepers had hoped the big cats would breed but have been left devastated after Asim, the male they brought in, attacked Melati. Sumatran tigers are the smallest surviving tiger subspecies and are distinguished by heavy black stripes on their orange coats.

Other news