The first successful birth of a child from a womb transplanted from a dead donor in Brazil should give hope to thousands of British women that they can have children, doctors said.
In the Brazilian case, the journal said the recipient had been born without a uterus due to a condition called Mayer-Rokitansky-Küster-Hauser syndrome.
The healthy baby girl was delivered last December to a 32-year-old woman who wasn't born with a uterus.
It was then transplanted to the woman who was given medication to weaken her immune system so her body would not reject the uterus. In this case, a cesarean section was performed for birth at 35 weeks gestation, and along with the delivery of an nearly 6 pound healthy baby girl, the uterus was also removed.
In 2011 a team in Turkey was the first to transplant a uterus from a deceased donor, but the procedure did not lead to a live birth. But they said that relying on deceased donors could expand the options for women who do not have a friend or family member willing to donate or that would be a good match.
Eleven children have been born following uterine transplantation from living donors, the first of which occurred in Sweden in September 2013.
Uterus transplants have become more common in recent years, resulting in 11 live births around the world. Ten previous attempts using deceased donors in the Czech Republic, Turkey and the us have failed. Previous live donor transplantation have waited at least a year before attempting a pregnancy.
They also note that it could potentially make uterus transplantsmore widely available, especially in countries that already regulate and distribute organ donations from deceased donors.
Both the mum and baby were discharged three days after birth, with an uneventful early follow-up.
"It enables use of a much wider potential donor population, applies lower costs and avoids live donors' surgical risks", Saso stated.
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The surgery involved connecting the donor uterus' and recipient's veins and arteries, ligaments, and vaginal canals.
He said any doubts he had about the potential importance of uterus transplants were erased after meeting the mother of the first baby born after a live donor uterus transplant.
Doctors implanted the fertilized eggs seven months after the procedure.
A team of doctors in Brazil have announced a medical first that could someday help countless women unable to have children because of a damaged or absent uterus.
But past treatments involving deceased donors failed. The recipient tolerated the transplant relatively well thanks to immunosuppression drugs, other treatments and constant monitoring. The donated uterus was then removed from the patient after the birth.
One in 500 women has uterine anomalies in the reproductive age group, reportsThe Lancet, pointing out that infertility affects 10-15% of couples.
"It is a breakthrough in the field of obstetrics as well as a great advantage for women who lost their uterus for some reason or don't have from birth".
It also "eliminates the main challenge", Singer added, "which is finding a matching donor and risking the lives of live donors who have to otherwise undergo a major surgery to remove their uterus".
In 2016, doctors at the Cleveland Clinic in OH transplanted a uterus from a deceased donor, but it failed after an infection developed.
"Uterine transplant is a novel technique and should be regarded as experimental", he said.
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