The Conservative MP added that it would be a "democratic travesty" if the public did not get to have their say once again.
Calling for a new referendum, Mr Johnson said: "My view is that this is so different from what was billed that it would be an absolute travesty if we do not go back to the people and ask them if they actually do want to exit the European Union on this extraordinarily hopeless basis".
"It has become increasingly clear to me that the withdrawal agreement, which is being finalised in Brussels and Whitehall even as I write, will be a bad mistake", he wrote.
It could be deployed in a bid to avoid a chaotic exit if no agreement can be reached or if a deal is voted down.
Prime Minister Theresa May this week faced pressure from her Westminster allies in the Democratic Unionist Party not to allow a customs border to split Northern Ireland from the United Kingdom after Brexit.
Serious impact?Image copyright PA Image caption Mr Johnson was elected MP for Orpington in 2010 and was made transport minister in January.
He is the sixth minister in Theresa May's government to quit over Brexit. "But we are not going to be bounced into another referendum, so that those who lost the previous one can try to apply continued membership of the European Union to the people of Britain in perpetuity".
Calling for a second referendum to be held on Brexit, Mr Johnson denounced the choice between Mrs May's deal plans or a no-deal scenario as a "failure of British statecraft on a scale unseen since the Suez crisis" that had left Britain facing "vassalage" or "chaos". I have never rebelled on any issue before now.
"My brother Boris, who led the leave campaign, is as unhappy with the Government's proposals as I am", he said. "But my duty to my constituents and our great nation has forced me to act".
Downing Street thanked him for his work but continued to insist there was no prospect of another referendum "under any circumstances".
"I think we are at a sensitive point in the negotiations, a successful outcome is not guaranteed but I think it is possible in the next couple of weeks", Varadkar said on Friday (November 9).
Johnson is the sixth minister to resign over Brexit in Theresa May's cabinet, following in the footsteps of his brother Boris, David Davis, Boris Johnson, Philip Lee, Steve Baker and Guto Bebb.
"This is a fascinating situation in which Jo and his sister are united in opposing their brother Boris and his Brexit plans".
Former BBC journalist and current University of Kent chancellor Gavin Esler said: "This - from a hugely respected minister - is an important development".
Johnson said this morning that other ministers are thinking hard about the Brexit and its implications.
In a blog for Medium, Johnson, brother of arch-Brexiteer and former foreign secretary Boris Johnson, writes: "Although I voted Remain, I have desperately wanted the government, in which I have been proud to serve, to make a success of Brexit: to reunite our country, our party and, yes, my family too".
The plane, which had only just taken off from Belfast City Airport, had reached 1,500 feet before its sudden descent began. As automated voices warned " don't sink " and " pull up , pull up", the flight commander disconnected the autopilot.
The group specifically examined competition concerns around how the deal would impact standard variable tariff (SVT) prices. Completion of the merger is expected to be delayed beyond the first quarter of 2019.
After Phase 2 is deemed a success, it will undergo another round of clinical testing and then apply for approval at the U.S. Nexvax2 is now being tested in a phase 2 clinical trial in Australia that includes patients from the United States.
After mysteriously losing his jump shot halfway through his rookie season, Markelle has looked much better so far in 2018. If the Sixers can hold off the Pacers in the closing minutes, they'll get their first road victory of the season.
They should be back where they belong in no time, which is being one of the top teams in the Western Conference. One young fan held up a sign that read "wherever (you) go I'll follow". "I'll leave it at that".
The Cleveland Indians will listen to trade packages for both Corey Kluber and Carlos Carrasco , according to ESPN's Buster Olney. Cashman repeated he intends to trade pitcher Sonny Gray , just 15-16 since NY acquired him from Oakland in July 2017.
A van linked to Sayoc has also emerged, showing heavy anti-Hillary stickers and pro-Trump stickers plastered all over its surface. One image showed the president standing on a tank with a rifle, complete with United States flag and fireworks.
Gary Woodland shot 2-over 73 in Round 2 but still made the cut on the number, extending his Tour-best cuts made streak to 15. Going back to an old driver didn't help as he hit only six fairways, making it tough to score for anyone out of the rough.
Marketing tactic or not, it is nice of Bethesda to be so optimistic. " How long is [Fallout 76] going to be up? " . Additionally, we'd love to hear about your experiences with Fallout 76 as you participate in B.E.T.A. testing.
Redmond Hospital Improves Its Safety Score
WakeMed Cary was worse than the national average in blood infection rates, one of the key measures recommended by Leapfrog. But some data on hospital-acquired conditions patient safety indicators cover incidents between 2015 and 2017.
Oil set for longest losing run since 2014 as supply fears ease
Brent was 30 cents a barrel lower at $70.35 by 0850 GMT, down 3.5 percent for the week and more than 15 percent this quarter. China National Petroleum Corp (CNPC) said on Friday that it was still taking oil from Iranian fields in which it has stakes.
Beat Saber PS4 Gets Release Date
There's no word on a price just yet, but this should round out what has turned out to be an excellent year for PSVR. We don't have them yet, but we'll publish a story as soon as we pick up the Beat Saber Trophies .
May pays WWI respects in France with Brexit in background
But his comments drew fire from the opposition as well as Jewish leaders on a still painful chapter in France's history. France's leading Jewish organization, known by the initials CRIF, issued a searing criticism of Macron's stance.
Oshie leaves twice, scores winner to lift Caps over Pens
Oshie, who returned and scored the game-winner with 1:14 left, was not mad at Malkin for what he perceived to be an accident. The Capitals (also 6-4-3) did some line tinkering before Monday night's game against the Edmonton Oilers and it paid off.