Federer, like any great champion, refused to throw in the towel and showed emotion for the first time after breaking for a 4-2 lead in the fourth.
He finished with 77 unforced errors and 10 double faults but had a host of chances to take wrap up matters in straight sets, squandering set points in the second and third sets.
Roger Federer fell victim to one of the great upsets in US Open history this morning.
More shocking than his departure was the manner of the 3-6 7-5 7-6 (7) 7-6 (3) loss to the Australian, with Federer simply wilting in the suffocating humidity and exiting a Grand Slam before the quarter-finals for just the fifth time since 2004.
Federer had cruised through the first set against Millman who was appearing in his maiden last-16 at the majors. Before the start of the grass-court season, Federer invited Millman to train with him in Switzerland.
Still, this was a stunner. Not simply because Federer lost - he entered the day 28-0 at the U.S. Open, and 127-1 in all Grand Slam matches, against foes below No. 50 in the ATP rankings - but how he lost.
Federer endured massive struggles with his serve throughout the fourth-round clash, the second seed finishing the encounter with a first-serve percentage of 49.
The crowd on Arthur Ashe, who were overwhelmingly behind the Swiss, could not believe what they were seeing.
But he gave the break back in the next game after slamming an overhead into the bottom of the net on game point.
Franklin funeral pastor apologises to Ariana Grande
Former President Bill Clinton became awestruck Friday at Aretha Franklin's funeral in Detroit , but he wasn't overcome with grief. We are all about love. "Author Mona Eltahawy added: "I don't care what you think about Ariana Grande , her music or her dress".
And then there was his serve.
Keys, who has made at least the quarterfinals in three of the four Grand Slams this year, fired six aces and had no double faults to dispatch Cibulkova in short order.
Federer took the opening set courtesy of a break in Millman's first service game. The 36th-ranked Tsurenko, who upset Caroline Wozniacki, left the court after the first set because of the heat and was a different player when she returned.
"When I was a break down in the final set I thought I would even break a leg if needed so I could get to every ball".
Federer said the unfancied Australian handled the heat better than he did.
Sept 3, 2018; New York, NY, USA; Novak Djokovic of Serbia tries to cool off in the heat during a change over while playing Joao Sousa of Portugal in a fourth round match on day eight of the 2018 U.S. Open tennis tournament at USTA Billie Jean King National Tennis Center.
Not in terms of money, but more just a hearty thank you.
Sharapova collected the trophy in NY at age 19 in 2006 and owns a total of five Grand Slam titles, but the Russian was far shakier than Suarez Navarro, who has never made it to the quarterfinals of a major.
Elsewhere in the men's bracket, No. 7 seed Marin Cilic moves on to meet No. 21 seed Kei Nishikori in a quarterfinal.
While the president is often greeted by protesters when he travels, this weekend's events coincided with services for McCain. Joining them were family and friends as well as members of McCain's Class of 1958, military leaders and academy midshipmen.
They split the $80 to buy the poster from Office Depot, and once it arrived, they took the steps to buy a McDonald's uniform. "I noticed there was a blank wall at McDonald's so I chose to make this fake poster of me and my friend", wrote Maravilla .
NY rapper Ja Rule and Machine Gun Kelly are just two of the endless name-drop victims on the new Kamikaze album speaking out. Machine Gun Kelly has cited Eminem as one of his idols who inspired him to rap.
The newsreader confessed that she is "not scared of dying" but has fears about leaving Freddie and her husband behind. Before joining 5 live Rachael worked at BBC Wiltshire. "I would really like to see it published before I die.
In a statement, Channel 2 News said it thanked Lewinsky for her appearance, "and we respect her sensitivity and wish her luck". Lewinsky simply answered: "I'm sorry, I'm not going to be able to do this", and quickly walked off the stage.
Jon Gruden's ex-ESPN partner takes a shot: What is he doing?
The sudden void left by Mack took its toll on the locker room, with players still adjusting to the news days after the trade. Sure, sending the Bears a 2020 fifth-round pick is nearly negligible - but they also sent a 2020 second-rounder as well.
Sharapova out of US Open in 4th round
The Spaniard, who turned 30 on Monday, will be at that stage for the second time at the U.S. More than a decade later, she can't seem to make it past the fourth round.
Turkish central bank to act on record inflation
Mr Erdogan fears that higher interest rates will smother borrowing and lead to slower economic growth. Producer prices rose 6.6 percent month-on-month in August for an annual rise of 32.13 percent.
Sequel to Razer's gaming phone in development
Gaming company Razer entered the competitive smartphone segment previous year , with the launch of the Razer Phone. Not just a phone, the company will focus on bringing more of its software offerings from PC to mobile.
Paul McCartney talks of seeing God during drug trip
Describing the encounter as a clue that there is "something higher" rather than a life-changing moment, he added: "It was huge". The Globe's top picks for what to see and do each weekend, in Boston and beyond.
Oil Climbs as Market Eyes Iran Supply Risks
Japan has been asking for a waiver from its ally, saying imports of Iranian crude have been recently falling. Brent crude, the global benchmark, was up 0.58% to $78.09 a barrel on London's Intercontinental Exchange.