New Mayo Clinic research to help pancreatic cancer patients

From the loss of the founder’s mother to the disease to the president’s father as well the organization was launched in 1999 to support the people fighting the world’s toughest cancer. See the women and men who are leading the charge for all those

However, as the researchers discovered that genetic mutations in patients devoid of family history of the disease, they are endorsing genetic testing for all pancreatic cancer patients as new criteria for care.

Patients diagnosed with pancreatic cancer can develop elevated blood sugar levels up to three years before their cancer diagnosis.

"Due to increased research investment, in recent years we have seen outstanding progress in other cancers such as breast and prostate, and a shocking lack of progress for pancreatic".

While receiving a diagnosis of type 2 diabetes is common for U.S. adults, African American and Latino adults over age 50 who receive a new diabetes diagnosis may have another health issue to be concerned about: pancreatic cancer.

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Pancreatic Cancer UK said the new survival rate was unacceptable, and has called for greater investment in research funding. This is because the vast majority of patients with pancreatic cancer (about 80% of them) detect disease at a late stage. The test results of 21 cancer genes were compared to similar results from more than 123,000 patients without pancreatic cancer. This is the primary study to offer approximates on the immensity of cancer risk related with each gene.

The model, called an ENDPAC score, identifies a subset of patients with new-onset diabetes that have a thirty to forty-fold higher risk of having pancreatic cancer and among them, the risk of having the disease is between four and seven percent, Chari said.

Matrisian added, "We strongly recommend all pancreatic cancer patients to undergo molecular profiling of their tumor, so adding germline testing can enhance the information gathered about that patient's disease, their treatment options and how their relatives may be affected as well". In cases in which patients had both pancreatic cancer and diabetes, 52.3% of patients developed diabetes in the 36 months preceding their cancer diagnosis. Pancreatic cancer following incident diabetes in African Americans and Latinos: the Multiethnic Cohort [published online June 18, 2018.] J Natl Cancer Inst. doi: 10.1093/jnci/djy090.

Diabetes was associated with an approximately twofold increased risk of pancreatic cancer. Importantly, the researchers demonstrated that the association of recent-onset diabetes with pancreatic cancer incidence was evident in African Americans and Latinos, two understudied minority populations with high risk of diabetes but different pancreatic cancer rates. "Our findings strongly support the hypothesis that recent-onset diabetes is a outcome of pancreatic cancer and that long-standing diabetes is a risk factor for this cancer". Pancreatic cancer remains one of the deadliest forms, as 70-percent of those who are diagnosed die within a year.

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