Ibuprofen long-term use linked to infertility in men

Ibuprofen 'damages blokes' BALLS increasing their risk of being infertile'

The researchers found that, compared with the placebo group, the men who took ibuprofen experienced a 23 percent increase in levels of luteinizing hormone (LH) - a hormone that's secreted by the pituitary gland and stimulates the production of testosterone - after two weeks.

Researchers found that young men who took ibuprofen in doses commonly used by athletes developed a hormonal condition linked to reduced fertility.

'Through a clinical trial with young men exposed to ibuprofen, we show that the analgesic resulted in the clinical condition named "compensated hypogonadism" - a condition prevalent among elderly men and associated with reproductive and physical disorders, ' explains Dr David Kristensen, of Copenhagen University.

Bernard Jégou, co-author and director of the Institute of Research in Environmental and Occupational Health in France, said the short-term effects in males are reversible but it is not known if the long-term effects are reversible.

The problem ranges worldwide: The World Health Organization says that one of every four couples spends at least five years unsuccessfully trying to get pregnant.

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Jegou said the findings do not in any way discourage the use of ibuprofen when it is needed. No doubt, more research will be conducted to make a more solid conclusion with regards to the effects of the common drug and what people should do about it. The painkiller users could potentially face prolonged low testosterone levels after the body loses its ability to compensate, leading to a host of health conditions including muscle weakness and loss, low fertility, and other issues.

"The study shows that ibuprofen use results in selective transcriptional repression of endocrine cells in the human testis", the significance on the PNAS site reads.

Professor Allan Pacey of the University of Sheffield stated that ibuprofen uses for a long-term goal can affect the hormonal production in males.

The widely-used over-the-counter painkiller ibuprofen may pose a threat to male fertility, suggests a small new study. The recent study comes about ibuprofen needs to be watched by men especially. Writing in the Proceedings of the National Academy of Sciences, the authors call for further studies into possible negative effects of hormonal changes caused by ibuprofen. "It is sure that these effects are reversible", he said. However, it is recommended that if men (or women) need to take it for more than three days consecutively then they should first consult their family doctor'.


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