Newborns have a relative abundance of brown fat, which protects against exposure to cold temperatures. Therefore, for a long time, specialists and researchers have tried to find the way to turn white fat into brown fat to fight fat accumulation and metabolic disorders.
Experiments on mice at Columbia University Medical Centre revealed that drugs converting surplus white fat into energy-burning brown fat could be successfully targeted via patches.
Although there are available drugs that promote browning, all of these are administered as pills or injections, which can cause unwanted side effects such as bone fractures, weight gain and stomach upset. The drugs are put into nanoparticles, microscopic containers exponentially thinner than a strand of hair.
These nanoparticles were loaded into a finger-tip sized skin patch containing dozens of microscopic needles that pierced the skin.
Nanoparticles located in the needles are released into the underlying tissue and spreading the drug across the body. While diet and exercise aren't able to "spot treat" fat - that is, eliminate it from just one part of the body - this micro-needle patch can.
In lean mice, treatment with drug-containing patches boosted the oxygen consumption by about 20 percent. New patches were applied every three days for four weeks. Control mice were also given two empty patches.
Trump, lawmakers squabble over whether they struck a deal
They do really well and work so hard, and for it to just be taken away like that? Sinema, witnesses in the room said, just smiled. Trump's willingness to support DACA, had fans like this one, who see the program as a form of amnesty, incensed.
The new approach has been tested in obese mice and showed a 20 percent reduction in fat on the treated fat compared to fat that was untreated.
They also had significantly lower fasting blood glucose levels than untreated mice.
Doctors say it could soon be used to treat obesity and diabetes after successful trials in mice.
Upon conducting genetic analyses, the researchers likewise found that the treated side had more genes linked to brown fat, suggesting that the "melting" of fat can be attributed to the browning process. Even better and more importantly, the patch could serve as a future treatment for metabolic conditions or diabetes. Researchers say that now the patch is not compatible with humans, but they'll keep investigating to adapt it. But all of these now exist only in pill and injection form.
This new skin patch appears to have mastered the process of browning. The other contributors are Yuqi Zhang (University of North Carolina at Chapel Hill and North Carolina State University, Raleigh, NC), Qiongming Liu (CUMC), Jicheng Yu (University of North Carolina and North Carolina State University), Shuangjiang Yu (University of North Carolina and Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, Jilin, China), and Jinqiang Wang (University of North Carolina).
The Bosnian has become an instant hit with the Emirates faithful owing to his tough defending as well as his attacking prowess. Can the same be said for Chelsea? Surely they are going to be unsafe against any team in the world.
But aside from the dominant Red Bulls, Hamilton was half-a-second clear of his fourth-placed Mercedes team-mate Valtteri Bottas . At Monaco and Hungary which are both notoriously hard to overtake on Ferrari secured a 1-2 and left Mercedes lagging behind.
Alabama LBs Rashaan Evans (groin), Anfernee Jennings (ankle) and Dylan Moses were all held out of the game on Saturday. Alabama returns to action Saturday, Sept. 23, with its SEC opener against Vanderbilt in Nashville, Tenn.
In July, Iraq retook control of Mosul, Islamic State's key stronghold in the north, after a campaign of almost nine months. In recent months, Islamic State has suffered a series of military setbacks and lost ground in Iraq and Syria.
Frankly, we're just confused by the iPhone 8 - the regular phone - since it's basically a slightly refreshed regular sized phone. But maybe the biggest effect of such a big and compelling screen is that it makes your phone more attractive and enticing.
While both corners proved to be up to the challenge, each will likely be counted on to play large roles again against the 49ers. And typically the Seahawks have beaten the 49ers by getting back to basics, averaging 160 yards rushing in those four wins.
For much of regulation, what was hyped as a rematch-for-the-ages between No. 4 USC and Texas didn't live up to its billing. The turning point in the second overtime came when the Trojans defense forced a fumble with Texas threatening to score.
After breaking, Branch found some success on the feet, tagging Rockhold with a number of punches as the former champ backpedaled. Rockhold has been out of action since UFC 199, when he was violently knocked out by Michael Bisping inside the first round.
Additionally, North Korea threatened to reduce the U.S.to "ashes and darkness" and sink Japan, leaving the Nikkei in the red. Gold fell after a European Central Bank official called for scaling back the bank's stimulus program.
Liverpool dominated possession early and often, cutting off Burnley passes at ease and pushing their opponents back. Coutinho returned for Liverpool on Wednesday in their 2-2 draw with Sevilla in the Champions League.
Meanwhile, roughly 6.4 million people in the state remained without power as of Wednesday afternoon, down from 13 million . City Electric Utilities Director Garey Edwards said the city crews could help out restoring power for at least two weeks.
Some Florida utilities, including FPL, had warned customers it could take weeks to restore power in the hardest hit areas. Dennen, the Korean War vet, said he's counting on his small generator and the kindness of neighbors to get by.
Mississippi State pulls off upset of No. 12 LSU
Also, Etling, because Mississippi State's defense was the first this season to force him to move, had a awful passing night. Alabama, 3-0 after a win over Colorado State Saturday, will continue to occupy the throne until someone else grabs it.
Tigers thrashed by Purdue in demoralizing loss
MISSOURI: The Tigers return to Southeastern Conference play with a home game against Auburn. I just did my job, however many plays I had to do it and that's what I'm trying to focus on.
SC receiver Samuel out for season
Kentucky junior LB Jordan Jones (shoulder) has been ruled out for Saturday's game against SC . He had five catches for 122 yards, including a 68-yard touchdown catch to open the game.
Oklahoma overcomes slow start in 56-14 win over Tulane
Tulane took advantage of any distractions and pounded the ball on the ground fairly successfully through the first quarter. Oklahoma takes on Tulane this afternoon, so there's a pretty good chance the Sooners will be 3-0 heading into Big 12 play.